CLS >2010 |
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| Engine | Original Power | Stage 1 | Difference | Vmax |
| 300 (3.5i) | 185 kW (252 hp) 340Nm | 202 kW (275 hp) 370Nm | 23 hp | ✓ |
| 350 (3.5i) | 225 kW (306 hp) 370Nm | 242 kW (330 hp) 400Nm | 24 hp | ✓ |
| 350 BlueEFFIENCY (3.5i) | 225 kW (306 hp) 370Nm | 242 kW (330 hp) 400Nm | 24 hp | ✓ |
| 400 EU6 (3.5T) | 245 kW (333 hp) 480Nm | 294 kW (400 hp) 580Nm | 67 hp | ✓ |
| 550 (4.6i) | 300 kW (408 hp) 600Nm | 375 kW (510 hp) 810Nm | 102 hp | ✓ |
| 500 EU6 (4.7T) | 301 kW (408 hp) 600Nm | 368 kW (500 hp) 800Nm | 92 hp | ✓ |
| 63 AMG (5.5T) | 386 kW (525 hp) 700Nm | 426 kW (580 hp) 900Nm | 55 hp | ✓ |
| 63 AMG (5.5T) | 409 kW (557 hp) 720Nm | 456 kW (620 hp) 950Nm | 63 hp | ✓ |
| 63 AMG Perf. (5.5T) | 409 kW (557 hp) 720Nm | 456 kW (620 hp) 950Nm | 63 hp | ✓ |
| 63 AMG S (5.5T) | 430 kW (585 hp) 800Nm | 456 kW (620 hp) 950Nm | 35 hp | ✓ |
| 220 CDI S&S (2.1) | 125 kW (170 hp) 400Nm | 154 kW (210 hp) 500Nm | 40 hp | ✓ |
| 250 CDI S&S (2.1) | 150 kW (204 hp) 480Nm | 176 kW (240 hp) 550Nm | 36 hp | ✓ |
| 350 CDI (3.0) | 195 kW (265 hp) 620Nm | 221 kW (300 hp) 700Nm | 35 hp | ✓ |